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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Time-dependent LPS exposure commands MSC immunoplasticity through TLR4 activation leading to opposite therapeutic outcome in EAE

Fig. 5

MSCs-TLR4KO loss their therapeutic potential in EAE. MSCs-TLR4KO or MSC WT primed or not with LPS (500 ng/m for 1 or 48 h) were injected 7 days after EAE induction. Clinical symptoms and weight loss were evaluated daily. a Clinical score, b cumulative clinical score, and c Kaplan-Meier curve for survival evaluation. Representative data of three independent experiments. Data are expressed as mean ± SEM; n = 12. * symbol represents the comparison against EAE control group. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001. δ symbol represents the comparison EAE+MSCs group vs. MSCs treated with LPS. δ p < 0.05, δδ p < 0.01, δδδ p < 0.001, δδδδ p < 0.0001. Statistics used was two-way ANOVA

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