Skip to main content
Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Direct lineage tracing reveals Activin-a potential for improved pancreatic homing of bone marrow mesenchymal stem cells and efficient ß-cell regeneration in vivo

Fig. 2

Transplantation of GFP+BMSC into STZ induced diabetic mice model. a Experimental design and timeline for the development of STZ diabetic mice and assessment of pancreatic regeneration with GFP+BMSC in combination with Activin-a. b Evidence for the establishment of diabetes and pancreatic injury after STZ injections by representative pancreatic histology (H&E) and immunostaining for insulin (red). Graphical representation of fasting c blood glucose and d serum insulin levels in control and STZ treated mice. Data represent mean ± SEM with N = 3 mice per group. e Validation of GFP expression in recipient STZ treated mice pancreas using flow cytometry and immunostaining for insulin (red). Graphs represent f fasting blood glucose and g serum insulin levels in controls and donor transgenic BMSC recipient mice. Data represent mean ± SEM with N = 3 mice per group. All statistical analysis was performed using Graphpad Prism software using two-way ANOVA and Bonferroni test for p value calculations

Back to article page

Stem Cell Research & Therapy

ISSN: 1757-6512