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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Direct lineage tracing reveals Activin-a potential for improved pancreatic homing of bone marrow mesenchymal stem cells and efficient ß-cell regeneration in vivo

Fig. 3

Quantification of GFP+BMSC in recipient mice pancreas and liver tissues. FACS analyses dot plots representing percentage population migrating to the a pancreas and b liver tissues in diabetic and donor BMSC recipient mice. Graphs present quantification of the mean frequency of GFP+ cells in both pancreas and liver tissues in all groups of animals. Data represent mean ± SEM with N = 3 mice per group. c Immunophenotyping of CD44 and GFP-expressing cells in FACS sorted total pancreatic cell suspension. Graphs representing quantification of d total CD44+ cells; e CD44+GFP+ dual population in harvested mice pancreas. f Graph showing quantification for the extent of endocrine differentiation in migratory donor BMSCs by reduced CD44 expression. This is calculated by subtracting CD44+GFP+ dual population from the total GFP+ population. Data represent mean ± SEM with N = 3 mice per group. All statistical analyses were performed using Graphpad Prism software using two-way ANOVA and Bonferroni test for p value calculations

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