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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Parathyroid hormone (1-34) promotes the effects of 3D printed scaffold-seeded bone marrow mesenchymal stem cells on meniscus regeneration

Fig. 6

Histological and immunohistochemical observation and evaluation of the knee joint cartilage. a H&E staining of the femoral condyle and tibial plateau cartilage (scale bar = 250 μm). b The Mankin score of histology of femoral condyle and tibial plateau cartilage. The PTH + BMSCs–scaffold group showed lower cartilage degeneration than the BMSCs–scaffold and the Meniscectomy groups. c SO/FG staining and immunohistochemical staining of tibial plateau for cartilage ECM component GAG and Col2 and matrix degradation markers Adamts5 and MMP13 (scale bar = 100 μm). d Semiquantitative analysis of SO/FG staining and immunohistochemical staining. Values for integrated optical density per area (IOD/area) of GAG and Col2 in the PTH + BMSCs–scaffold group were higher and those for Col10 and MMP13 were significantly lower than that in the BMSCs–scaffold group (*P < 0.05, **P < 0.01)

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