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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: The effect of aging on the biological and immunological characteristics of periodontal ligament stem cells

Fig. 3

PBMCs proliferation and apoptosis. a APDLSCs and YPDLSCs could both significantly inhibit the proliferation of PBMCs that were stimulated by PHA, but the ability of APDLSCs to inhibit PBMC proliferation was weaker than YPDLSCs. b Delayed addition of PDLSCs from different age groups could also inhibit PBMCs proliferation, but the ability of APDLSCs to inhibit PBMCs proliferation was weaker than YPDLSCs. c On the two-way mixed lymphocyte reaction (MLR), APDLSCs and YPDLSCs could both inhibit PBMCs stimulated by allogeneic PBMCs, but the ability of APDLSCs to inhibit PBMC proliferation was weaker than YPDLSCs. d PBMCs inhibited by PDLSCs from different age groups could be reactivated when stimulated with PHA, but PBMCs inhibited by APDLSCs were more easily reactivated and proliferated faster than those inhibited by YPDLSCs. e PDLSCs from different age groups could inhibit the proliferation of PBMCs in Transwell culture, but the ability of APDLSCs was weaker than YPDLSCs. f, g There is no statistical difference in the number of apoptotic PBMCs between the co-culture group containing APDLSCs and PBMCs and the co-culture group containing YPDLSCs and PBMCs. The young group had three independent donors, and the adult group had three independent donors. Data are presented as mean ± SD of three independent experiments (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, N.S., no significance)

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