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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Alleviation of acute radiation-induced bone marrow failure in mice with human fetal placental stromal cell therapy

Fig. 4

Spleen and liver sites of extramedullary hematopoiesis. a Spleen weight at the termination of the follow-up. Increased spleen weight was associated with elevated number of megakaryocytes only in TBI IM or SC f-hPSC-treated mice, as compared to the naïve controls (b). The spleen cellularity and size, which may represent the extent of spleen damage which varied in the few surviving Veh-Cont mice, are presented (c Vs d, with magnification of selected area). Increased total number of spleen cells and the presence of HSCs (identified as Lin- negative, [cKit+, SCA1+ and CD150+) in f-hPSC-treated mice, as compared with Veh-Cont and Naïve mice, may suggest increased Spleen-EMH. Total numbers of isolated cells, HSC frequency, and their total counts in the spleen are presented in e–g (p values:*< 0.05, **< 0.01, ***< 0.001, ****< 0.0001)

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