Skip to main content
Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Plasticity of Paneth cells and their ability to regulate intestinal stem cells

Fig. 1

PCs located in crypt provide support to stem cells by secreting EGF, Wnt3a and DLL4. Under injury condition, PCs acquire stem features and generate all type of intestinal epithelial cells by activating Notch and Wnt signals. The lamina propria consists of multiple components and cell types, including mesenchymal cells, fibroblasts, neural cells, T cells and macrophage cells; they promote stem cell proliferation by activating Wnt signalling pathway or secreting cytokines (e.g. IL-22, IL-6 and GLP-2). Other differentiated cells such as enteroendocrine cell and enterocyte can restore stem features and promote damage repair

Back to article page