Fig. 5

Transcriptomic profiles of control vs culture-aged TMSCs. An analysis of RNA whole-genome sequence data from control and culture-aged TMSC is presented. a A heatmap of hierarchical clustering analysis results indicate differentially expressing genes (rows) between the control and culture-aged TMSCs. Yellow and blue bars indicate upregulated and downregulated genes, respectively, in the culture-aged TMSCs in comparison to the control. For all comparisons, changes in gene expression are depicted as a heatmap. b MDS plots for microarray gene expression data compared control and culture-aged TMSCs. c Dendrogram depicting the results of hierarchical clustering analysis of the interclass correlation between control and culture-aged TMSCs, confirming classification of an interclass between the two groups. d The number of upregulated or downregulated genes between control and culture-aged TMSC groups with fold changes of at least 1.5 (1.5fc) or 2 (2.0fc) are presented