Fig. 1

The Kaplan-Meier plots for the survival of mice treated with combinations of commercially available drugs. Mice were intraperitoneally administered a clinical dosage (10 μg/kg of body weight/day) of G-CSF and RP, starting within 2 h after 7-Gy dose of TBI. As shown in Table 1, the medications were administered in 4 different combinations (n = 10 in each group): a G-CSF once-daily for 3 times and RP once a week for 2 times (GRP #1), b G-CSF once-daily for 3 times and RP once a week for 3 times (GRP #2), c G-CSF once-daily for 3 times and RP once a week for 4 times (GRP #3), and d G-CSF once-daily for 4 times and RP once a week for 3 times (GRP #4). In addition, mice were intraperitoneally administered the GRP #4 starting within 2 h after e 7.25 Gy or f 7.5 Gy of TBI (n = 5 in each group). Mice treated with TBI only received injections of the normal saline solution as vehicle. “7 Gy + GRP,” “7.25 Gy + GRP,” or “7.5 Gy + GRP” and “7 Gy,” “7.25 Gy,” or “7.5 Gy” indicated the results of TBI mice with and without each medication, respectively. Statistically significant differences were evaluated by the log-rank test compared with TBI only (P < 0.05)