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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance via PTEN-mediated crosstalk between the PI3K/Akt and Erk/MAPKs signaling pathways in the skeletal muscles of db/db mice

Fig. 2

HUC-MSC transplantation ameliorates IR in the skeletal muscle of db/db mice. a Bioluminescence imaging detected the colonization of HUC-MSCs following IM transplantation, red arrows show colonization of HUC-MSCs. b Skeletal muscle tissue sections from each mouse were stained with ANA and assessed using immunofluorescence, ANA (green), nuclear (blue), red arrows show the positive of ANA. Magnification, × 400. c Insulin resistance index. The results are representative of 3 independent repeats. Data are presented as the mean ± standard deviation. **P < 0.01 vs. baseline levels in db/m. ##P < 0.01. HUC-MSC, human umbilical cord-mesenchymal stem cells; IR, insulin resistance

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Stem Cell Research & Therapy

ISSN: 1757-6512