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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance via PTEN-mediated crosstalk between the PI3K/Akt and Erk/MAPKs signaling pathways in the skeletal muscles of db/db mice

Fig. 4

HUC-MSC treatment ameliorates IR through regulating the activation of PI3K/Akt signaling in the skeletal muscle of db/db mice. a The intensity of immunohistochemical staining for PI3K, p-Akt, and GLUT4 were evaluated based on the optical density by fixed skeletal muscle tissues. Representative images tissues from mice in each group are presented. Magnification, × 400. b Protein expression levels of PI3K, p-PI3K, Akt, p-Akt, IR, and p-IR in skeletal muscle tissues. c mRNA expression levels of IRS, GLUT4, GSK3β, FoxO1, and mTOR. *P < 0.05 **P < 0.01 vs. the baseline levels (db/m). Data are presented as the mean ± standard deviation. #P < 0.05, ##P < 0.01 between db/db and db/db+HUC-MSCs. The results are representative of 3 independent repeats. HUC-MSC, human umbilical cord-mesenchymal stem cells; IR, insulin receptor

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