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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: Human umbilical cord-derived mesenchymal stem cells ameliorate insulin resistance via PTEN-mediated crosstalk between the PI3K/Akt and Erk/MAPKs signaling pathways in the skeletal muscles of db/db mice

Fig. 6

HUC-MSC treatment regulates the balance between PI3K/Akt and Erk/MAPK signaling by increasing PTEN expression in the skeletal muscle of db/db mice. a Fixed skeletal muscle tissues were stained with PTEN and p-PTEN antibodies, and the intensity of immunohistochemical staining was evaluated. Representative images of tissues from each group. Magnification, × 400. b PTEN and p-PTEN protein expression levels in skeletal muscle tissues. c mRNA expression levels of PTEN in skeletal muscle tissues. Results are representative of 3 independent repeats. Data are presented as the mean ± standard deviation. *P < 0.05, **P < 0.01 vs. the baseline levels (db/m). #P < 0.05, ##P < 0.01

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Stem Cell Research & Therapy

ISSN: 1757-6512