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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson’s disease

Fig. 1

In vitro differentiation of hESCs to generate immature midbrain dopaminergic (mDA) neurons for transplantation. a Schematic of mDA neuron differentiation from hESC. b Immunofluorescence staining of neurospheres containing immature mDA neurons (TUJ1+/TH+) at day 48 of differentiation. Scale bar, 100 μm. c Western blot showing mDA neuron production of dopamine active transporter (DAT) and tyrosine hydroxylase (TH). d HPLC analysis showing immature mDA neurons mature and produce dopamine and DOPAC by day 40 of differentiation

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Stem Cell Research & Therapy

ISSN: 1757-6512