Skip to main content
Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson’s disease

Fig. 5

Authentic mDA identity and functional efficacy of the grafted TH+ cells and correlations between [18F]FBCTT imaging, TH count and behavioural recovery in mDA cell-transplanted PD rats. a Immunofluorescence staining for TH (green) and coexpression (red) with EN1 (b), LMX1A (e), FOXA2 (h) and GIRK2 (k). Scale bar, 50 μm. b IHC-DAB staining using hNCAM antibody revealed the innervation of the transplanted cells from the graft (G) into the surrounding host striatum (H). Scale bar, 100 μm. c A positive linear correlation between [18F]FBCTT binding (expressed as % of the contralateral uptake) and the number of TH+ cells per graft at 6 months post-transplantation. d No correlation between the amphetamine-induced rotation (expressed as % of pretransplant) and the number of TH+ cells per graft at 6 months post-transplantation. e The change in [18F]FBCTT binding (expressed as % of the contralateral uptake) in high-TH versus low-TH grafts at 1, 3 and 6 months post-transplantation. f The change in the number of rotations after amphetamine injection longitudinally in high-TH versus low-TH grafts at 1, 3 and 6 months post-transplantation

Back to article page