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Fig. 3 | Stem Cell Research & Therapy

Fig. 3

From: Reparative effect of mesenchymal stromal cells on endothelial cells after hypoxic and inflammatory injury

Fig. 3

MSC reduce injury markers on injured HUVEC. ad The expression of CD54, CD146, HLA-II, and Tie-2 on HUVEC membrane was increased after injury. After 24 h incubation with MSC at a 1:2 ratio, membrane markers were decreased to non-injured levels. No effects of HI-MSC or MSC separated from HUVEC through a transwell were observed. e Production of ROS by HUVEC was increased by hypoxia and reoxygenation. After 24 h incubation with MSC at a 1:2 ratio, ROS levels in HUVEC were decreased by 60%. No effects of HI-MSC or MSC incubated through a transwell were observed (n = 5). Results are shown as mean ± SD. Significance of the comparison between injured HUVEC and the effect of MSC is shown as **p value < 0.01 and *p value < 0.05

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