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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: miR-150 regulates endothelial progenitor cell differentiation via Akt and promotes thrombus resolution

Fig. 6

Therapeutic role of miR-150 in deep venous thrombosis. a HE staining showed that coinjection of eEPCs transfected with miR-150 and ECFCs promoted thrombus recanalization and resolution (× 400). b Weight of thrombus was tested at 7 days after transplantation. c Immunohistochemistry revealed more endothelial-specific marker CD34 expression in the EPCs/miR-150 plus ECFCs group as compared to other groups (× 400). d DSA images showed thrombus resolution in the inferior vena cava (IVC) in different groups (blank control, eEPCs, eEPCs transfected with miR-150 agomir plus ECFCs, and eEPCs transfected with NC agomir plus ECFCs). Black area in IVC indicated thrombus resolution. e The recanalization of thrombus was quantified with ImageJ software by the area ratio of contrast agent in vascular with thrombosis. (*P < 0.05 vs. blank control; **P < 0.01 vs. blank control)

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Stem Cell Research & Therapy

ISSN: 1757-6512