Table 1 Demographics and baseline characteristics of all patients
From: Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells
Variables | Total patients (n = 41) | hUC-MSC(N = 12) | Control (N = 29) | P value |
|---|---|---|---|---|
Age (mean ± SD) | 58.78 ± 16.26 | 61.00 ± 17.87 | 57.86 ± 15.79 | 0.576 |
Male sex, n (%) | 24 (58.54%) | 8 (66.67%) | 16 (55.17%) | 0.794 |
Comorbidities, n (%) | ||||
 Diabetes | 8 (19.51%) | 3 (25%) | 5 (17.24%) | 0.672 |
 Hypertension | 9 (21.95%) | 3 (33.33%) | 6 (20.69%) | 1.000 |
Signs and symptoms on admission, n (%) | ||||
 Fever ≥ 37.3 °C | 36 (87.80%) | 10 (83.33%) | 26 (89.66%) | 0.470 |
 Cough | 27 (65.85%) | 8 (66.67%) | 19 (65.52%) | 1.000 |
Respiratory rate > 24/min | 31 (75.61%) | 11 (91.67%) | 20 (68.97%) | 0.231 |
Routine bloodwork | ||||
 WBC count (× 109/L) mean (IQR) | 6.88 (5.06, 9.20) | 7.37 (5.06, 11.16) | 6.88 (5.06, 8.71) | 0.449 |
 3.5~9.5 (× 109/L), n (%) | 29 (70.73%) | 7 (58.34%) | 22 (75.86%) | 0.068 |
 < 3.5 (× 109/L), n (%) | 3 (7.31%) | 1 (8.33%) | 2 (6.89%) | 1.000 |
 > 9.5 (× 109/L), n (%) | 7 (17.07%) | 4 (33.33%) | 3 (10.34%) | 0.165 |
 LYM count (× 109/L) median (IQR) | 0.82 (0.59, 1.19) | 0.77 (0.43, 1.72) | 0.82 (0.59, 1.11) | 0.783 |
 < 1(× 109/L), n (%) | 18 (43.90%) | 5 (41.67%) | 13 (44.83%) | 1.000 |
 ≥ 1(× 109/L), n (%) | 23 (56.10%) | 7 (58.33%) | 16 (55.17%) | 1.000 |
 MON count (× 109/L) median (IQR) | 0.50 (0.32, 0.75) | 0.41 (0.26, 0.65) | 0.62 (0.33, 0.0.91) | 0.187 |
 Hb (g/L) mean (IQR) | 120.0 (112, 128.5) | 119.5 (100.3, 127.8) | 120.0 (112.0, 133.0) | 0.322 |
 PLT count (× 109/L) median (IQR) | 205.0 (145.0, 242.0) | 207.0 (170.5, 327.8) | 205.0 (141.0, 236.0) | 0.338 |
 < 100 (× 109/L), n (%) | 3 (7.32%) | 1 (8.33%) | 2 (6.90%) | 1.000 |
 ≥ 100 (× 109/L), n (%) | 38 (92.68%) | 11 (91.67%) | 27 (93.10%) | 1.000 |
 PT (s) median (IQR) | 12.30 (11.60, 13.20) | 11.85 (11.33, 13.10) | 12.40 (11.80, 13.20) | 0.296 |
 APTT (s) median (IQR) | 37.10 (32.53, 41.80) | 34.45 (29.60, 43.45) | 38.80 (34.00, 41.80) | 0.317 |
 D-D (μg/L) median (IQR) | 0.54 (0.02, 0.54) | 0.89 (0.24, 2.78) | 0.34 (0.20, 1.34) | 0.224 |
Myocardial enzymes | ||||
 CK (U/L) median (IQR) | 109.0 (40.5, 215.0) | 162.5 (75.0, 360.8) | 106.0 (36.0, 201.0) | 0.132 |
 < 310 (U/L), n (%) | 36 (87.80%) | 9 (75.00%) | 27 (93.10%) | 0.139 |
 ≥ 310 (U/L), n (%) | 5 (12.20%) | 3 (25.00%) | 2 (6.90%) | 0.139 |
 LDH (U/L) median (IQR) | 331.0 (229.0, 410.5) | 285.5 (220.0, 392.0) | 331.0 (237.5, 441.0) | 0.338 |
 < 250 (U/L), n (%) | 14 (34.15%) | 4 (33.33%) | 10 (34.48%) | 1.000 |
 ≥ 250 (U/L), n (%) | 27 (65.85%) | 8 (66.67%) | 19 (65.52%) | 1.000 |
Biochemical indicators | ||||
 ALT (U/L) median (IQR) | 56.00 (42.50, 74.50) | 67.00 (47.50, 104.00) | 42.50 (42.00, 74.50) | 0.065 |
 < 50 (U/L), n (%) | 9 (21.95%) | 2 (16.67%) | 7 (24.14%) | 0.702 |
 ≥ 50 (U/L), n (%) | 32 (78.05%) | 10 (83.33%) | 22 (75.86%) | 0.702 |
 AST (U/L) median (IQR) | 31.00 (24.50, 38.00) | 34.00 (25.25, 45.00) | 31.00 (24.00, 37.50) | 0.576 |
 < 40 (U/L), n (%) | 32 (78.05%) | 8 (66.67%) | 24 (82.76%) | 0.407 |
 ≥ 40 (U/L), n (%) | 9 (21.95%) | 4 (33.33%) | 5 (17.24%) | 0.407 |
 Cr (μmol/L) mean (SD) | 60.27 (49.28, 69.46) | 53.84 (44.97, 65.57) | 65.85 (49.41, 71.59) | 0.360 |
 BUN (mmol/L) median (IQR) | 5.05 (3.43, 6.15) | 5.43 (3.14, 6.59) | 4.83 (3.43, 5.90) | 0.827 |