From: Treatment of severe COVID-19 with human umbilical cord mesenchymal stem cells
Variables | Total patients (n = 41) | hUC-MSC (N = 12) | Control (N = 29) | P value |
---|---|---|---|---|
Time to clinical improvement-median, No. of days (IQR) | 13.00 (7.00, 18.50) | 9.00 (6.00, 13.00) | 14.00 (9.50, 21.00) | 0.006 |
Age ≤ 65 years- median, No. of days (IQR) | 9.50 (6.75, 14.00) | 6.00 (3.00, 7.00) | 12.00 (7.25, 15.50) | 0.0014** |
Age > 65 years –median, No. of days (IQR) | 17.00 (13.00, 23.00) | 13.00 (11.75, 14.00) | 23.00 (18.50, 29.00) | < 0.001*** |
Day 28 mortality, No. (%) | 3 (7.31%) | 0 | 3 (7.31%) | 0.543 |
Earlier (≤ 12 days after onset of symptoms) | 0 | 0 | 0 |  |
Later (> 12 days after onset of symptoms) | 3 (7.31%) | 0 | 3 (7.31%) | 0.543 |
Patients who progressed from severe to critical illness, No. (%) | 4 (9.76%) | 0 | 4 (13.79%) | 0.667 |
Clinical improvement, No. (%) | ||||
 Day 3 | 3 (7.32%) | 2 (16.67%) | 1 (3.45%) | 0.200 |
 Day 7 | 12 (29.27%) | 7 (58.33%) | 5 (17.24%) | 0.020* |
 Day 14 | 26 (63.41%) | 11 (91.67%) | 15 (51.72%) | 0.03 |
 Day 28 | 37 (90.24%) | 12 (100%) | 25 (86.21%) | 0.302 |
 Hospital stay, median, No. of days (IQR) | 22.00 (19.50, 25.00) | 20.00 (16.00, 24.00) | 24.00 (20.00, 26.50) | 0.054 |
Score on seven-category scale at day 7 of enrollment, No. of patients (%) | ||||
 2: Not hospitalized but unable to resume normal activities | 1 (2.44%) | 1 (8.33%) | 0 | 0.293 |
 3: Hospitalization, not requiring supplemental oxygen | 10 (24.39%) | 7 (58.33%) | 3 (10.34%) | 0.0028** |
 4: Hospitalization, requiring supplemental oxygen | 22 (53.66%) | 3 (25.00%) | 19 (65.52%) | 0.037 |
 5: Hospitalization, requiring HFNC or noninvasive mechanical ventilation | 6 (14.63%) | 1 (8.33%) | 5 (17.24%) | 0.651 |
 6: Hospitalization, requiring ECMO, invasive mechanical ventilation, or both | 2 (4.88%) | 0 | 2 (4.88%) | 1.000 |
 7: Death | 0 | 0 | 0 | 1.000 |
Score on seven-category scale at day 14 of enrollment, No. of patients (%) | ||||
 2: Not hospitalized but unable to resume normal activities | 10 (24.39%) | 5 (41.67%) | 5 (17.24%) | 0.124 |
 3: Hospitalization, not requiring supplemental oxygen | 23 (56.10%) | 6 (50.00%) | 17 (58.62%) | 0.734 |
 4: Hospitalization, requiring supplemental oxygen | 2 (4.88%) | 1 (8.33%) | 1 (3.45%) | 0.505 |
 5: Hospitalization, requiring HFNC or noninvasive mechanical ventilation | 2 (4.88%) | 0 | 2 (6.70%) | 1.000 |
 6: Hospitalization, requiring ECMO, invasive mechanical ventilation, or both | 1 (2.44%) | 0 | 1 (3.45%) | 1.000 |
 7: Death | 3 (7.32%) | 0 | 3 (10.34%) | 0.543 |