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Table 1 Demographic and laboratory data of the investigated pediatric β-thalassemia patients

From: CRISPR-mediated gene modification of hematopoietic stem cells with beta-thalassemia IVS-1-110 mutation

Variable Case 1 Case 2 Case 3 Case 4 Case 5 Case 6
Age (years) 10 years 8 years 2 years 1.5 years 4 years 3 years
Gender Male female Female Male Female Male
Duration of blood transfusion 8 years 7 years 1.5 years 1 year 3 years 2.5 years
RBCs (× 106/mm3) 3 3.2 3.8 4.1 3.2 4.6
Hb (g/dL) 8.5 9.2 9.5 10.1 9.4 9.2
Hematocrit (%) 28.9 30.2 30.9 30.4 29.5 30.2
MCV (fL) 70.5 69.6 71.4 65.4 72.4 74.6
MCH (pg) 25.4 22.4 25.6 24.6 26.1 25.9
MCHC (g/dL) 30.8 32.8 32.6 30.9 33.1 30.6
RDW (%) 18.6 17.5 16.9 17.5 18.4 18.6
TLC (× 103/mm3) 15.5 20.6 14.6 17.6 14.9 25.6
Platelets(× 103/mm3) 466 522 416 650 578 563
Reticulocytes (%) 6.5 5.4 10.2 8 4.5 5.5
Serum iron (μg/dL) 80 61 102 95 67 90
HbF (%) 80.2 84.6 74.02 66.4 70.2 88.4