Fig. 6
From: The anti-fibrotic effect of human fetal skin-derived stem cell secretome on the liver fibrosis
hFSSC secretome reduced liver fibrosis by regulating the TGF-β/Smad signaling pathway. hFSSC secretome inhibited TGF-β1expression and activated Smad7 expression which are activated by the binding of the TGF-β super family to the cell surface receptors. TGF-β1-mediated tissue fibrosis via Smad2/Smad3 which the two major downstream regulator, while Smad7 serves as a negative feedback regulator of TGF-β1/Smad pathway, thereby protecting against TGF-β1-mediated fibrosis. Furthermore, hFSSC secretome decreased the collagen I expression, thereby reducing liver fibrosis