Fig. 2

Effects of the combination of BM-MNCs and α7nAChR agonist (nicotine) on E. coli pneumonia. a–c Effects of intrapulmonary delivery of 3-day BM-MNCs on ELW, lung IL-10, and SCF in recipient mice with acute lung injury induced by E. coli. Student’s t test was used. ^*P < 0.05, ^**P < 0.01 versus the PBS group. N = 4 mice in each group. Data are shown as the mean ± SD. d Effects of the activation of α7nAChR by nicotine in BM-MNCs from d3 pneumonia mice on recipient pneumonia mice. One-way ANOVA was used. ^*P < 0.05, N = 3–4 mice in each group. e–g Engraftment of BM-MNCs obtained from d3 pneumonia mice in the recipient lungs with E. coli pneumonia. The recipient mice were sacrificed 7 days after BM-MNC transplantation. e Normal recipient mice; f d2 pneumonia recipient mice; g d3 pneumonia recipient mice. N = 3 mice in each group