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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Overexpressing TGF-β1 in mesenchymal stem cells attenuates organ dysfunction during CLP-induced septic mice by reducing macrophage-driven inflammation

Fig. 7

Macrophage depletion weakened the therapeutic effect of MSC-TGF-β1 in septic mice. a Depletion of macrophages using clodronate liposomes. b, c Histopathological images of lung tissues in normal or macrophages-depleted septic mice were obtained by H&E (× 400). Scale bar = 100 μm (n = 3, *p < 0.05 vs. the sham group; #p < 0.05vs. the CLP group; &p < 0.05vs. the MSC-NC group). Del, macrophage depletion; MSC-NC, mesenchymal stem cell carrying GFP; MSC-TGF-β1, mesenchymal stem cell carrying transforming growth factor-beta 1

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Stem Cell Research & Therapy

ISSN: 1757-6512