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Fig. 6 | Stem Cell Research & Therapy

Fig. 6

From: RETRACTED ARTICLE: microRNA-375 released from extracellular vesicles of bone marrow mesenchymal stem cells exerts anti-oncogenic effects against cervical cancer

Fig. 6

BMSC-derived EV-encapsulated miR-375 exerts an inhibitory effect on cervical cancer in vitro. a Migration and invasion of cervical cancer cells co-cultured with EVs isolated from miR-375-transfected BMSCs were evaluated using Transwell, assay. b Proliferation of cervical cancer cells co-cultured with EVs isolated from miR-375-transfected BMSCs was evaluated using EdU assay. c Apoptosis of cervical cancer cells co-cultured with EVs isolated from miR-375-transfected BMSCs was evaluated using TUNEL assay. d, e The expression of cell apoptosis-related proteins (Bcl-2 and Bax), cell cycle-related proteins (CDK4 and Cyclin D1), and cell migration-related proteins (E-cadherin and Vimentin) was assessed using Western blot analysis in cervical cancer cells co-cultured with EVs isolated from miR-375-transfected BMSCs, normalized to β-actin. The measurement data are presented as mean ± SD. Two groups of data are compared by an independent sample t test. *p < 0.05 compared with the NC group. The cellular experiment was repeated three times independently

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Stem Cell Research & Therapy

ISSN: 1757-6512