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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Optimal H2O2 preconditioning to improve bone marrow mesenchymal stem cells’ engraftment in wound healing

Fig. 7

Effect of optimal H2O2-preconditioned BMSCs on wound healing in mice. a Representative images of mouse CD31 staining of wounds in PBS, BMSC, and H2O2-preconditioned groups. Scale bar, 50 μm. b Microvessel density in the wounds was assessed by CD31-positive staining for microvessels, expressed as the number of CD31-positive microvessels per field. c H&E staining of wound granulation tissue in PBS, BMSC, and H2O2-preconditioned BMSCs groups at 5 days post-wounding. Scale bar, 50 μm. d Evaluation of collagen deposition by Masson staining at day 7 post-wounding. Representative × 40 image from the center of the granulation tissue of each group displaying cells and granulation within the wound center. Scale bar, 50 μm. e Qualification of the stain intensity of blue collagen shown in d. Data are shown as means ± SEM (n = 3). *P < 0.05 vs. the PBS group; ΔP < 0.05 vs. the BMSCs group

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