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Fig. 4 | Stem Cell Research & Therapy

Fig. 4

From: Multipotent adult progenitor cells grown under xenobiotic-free conditions support vascularization during wound healing

Fig. 4

XF-hMAPC cells dose-dependently induced granulation and re-epithelialization early during wound healing. ae Cross-sections representing an overview of the wound bed stained with hematoxylin/eosin (H&E) for the Plasma-Lyte control (“CTRL”; A; black circles in e; n = 14), low-dose XF-hMAPC cell (“XF1”; b; green triangles in e; n = 13), middle-dose XF-hMAPC cell (“XF2”; c; blue triangles in e; n = 15), and high-dose XF-hMAPC cell (“XF3”; d; red triangles in e; n = 16) groups and the corresponding quantification in e. Data represent mean granulation tissue amount, expressed as arbitrary units ± S.E.M. (*P < 0.05 versus indicated condition by one-way ANOVA). Granulation tissue area is lined by black dashed lines in ad. fj Cross-sections representing an overview of the wound bed stained for pancytokeratin (PCK) for the CTRL (f; black circles in j; n = 15), XF1 (g; green triangles in j; n = 16), XF2 (h; blue triangles in j; n = 14), and XF3 (i; red triangles in j; n = 16) groups and the corresponding quantification in j. Data represent mean re-epithelialization distance from the wound edges relative to the wound length expressed as % ± S.E.M. (*P < 0.05 versus indicated condition by one-way ANOVA). Red horizontal lines in fi indicate distance covered by the neo-epidermis. Outer wound edges are indicated by arrowheads in ad and fi. Hematoxylin was used as nuclear counterstaining (in blue) in ad and fi. Magnifications at which pictures were taken: × 2.5 in ad, fi. Scale bars: 500 μm in ad and fi

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