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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: Hepatocyte-like cells derived from human induced pluripotent stem cells using small molecules: implications of a transcriptomic study

Fig. 1

Small molecule-based protocol for the differentiation of hepatocytes from induced pluripotent stem cells. a Schematic diagram showing the three-phase differentiation process. b Representative images showing sequential morphological changes at each stage of the differentiation. iPSC, induced pluripotent stem cell; ME, mesendoderm; DE, definitive endoderm; HP, hepatic progenitor; HLC, hepatocyte-like cell. Magnification: × 10, Insert: × 40, Scale bar: 400 μm. c Representative immunocytochemistry images demonstrating the expression of key markers at each stage of the differentiation. The percentage of marker positive cells, presented as mean ± SD of three independent experiments, is listed at the bottom under each marker. Scale bar: 400 μm

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