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Table 2 KEGG pathways directly or indirectly involved in hepatocyte differentiation

From: Hepatocyte-like cells derived from human induced pluripotent stem cells using small molecules: implications of a transcriptomic study

Pathway

Count

P value

Fold enrichment

Pluripotency, differentiation, and development

 Signaling pathways regulating pluripotency of stem cells

27

0.0572

1.42

 Wnt signaling pathway

32

0.0027

1.71

 TGF-beta signaling pathway

22

0.0034

1.93

Cellular community

 Focal adhesion

50

0.0000

1.79

 ECM-receptor interaction

28

0.0000

2.37

 Adherens junction

18

0.0124

1.87

 Tight junction

21

0.0112

1.78

 Gap junction

18

0.0815

1.50

 Regulation of actin cytoskeleton

37

0.0795

1.30

 PI3K-Akt signaling pathway

67

0.0019

1.43

 Hippo signaling pathway

35

0.0017

1.71

Hepatocyte function

 Bile secretion

17

0.0203

1.81

 Insulin signaling pathway

26

0.0778

1.39

 PPAR signaling pathway

16

0.0324

1.76

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Stem Cell Research & Therapy

ISSN: 1757-6512