Hepatocyte-like cells derived from human induced pluripotent stem cells using small molecules: implications of a transcriptomic study

Table 3 List of 26 categories of upstream regulators identified for DEGs

	#	Predicted activation	Predicted inhibition
Biologic drug	33	1	5
Chemical - endogenous	230	11	17
Chemical - kinase inhibitor	43	0	10
Chemical - protease inhibitor	14	2	0
Chemical - other	6	0	0
Chemical drug	423	27	80
Chemical reagent	104	7	15
Chemical toxicant	108	18	8
Complex	70	13	9
Cytokine	56	11	6
Enzyme	258	28	25
Fusion gene/product	16	3	3
G-protein coupled receptor	41	7	1
Group	113	16	11
Growth factor	64	29	2
Ion channel	10	1	1
Kinase	150	28	8
Ligand-dependent nuclear receptor	35	4	5
MicroRNA	110	0	47
Peptidase	50	10	1
Phosphatase	23	2	0
Transcription regulator	480	78	50
Translation regulator	16	3	0
Transmembrane receptor	56	7	3
Transporter	63	5	5
Other	386	53	26
Total	2958	364	338

ISSN: 1757-6512