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Table 4 List of 52 upstream transcription factors within the DEGs

From: Hepatocyte-like cells derived from human induced pluripotent stem cells using small molecules: implications of a transcriptomic study

Transcription regulator

Fold change

Predicted activation

Activation z-score

P value of overlap

# Target molecules in dataset

HNF4A

− 3.385

Inhibited

− 5.745

2.70E−27

750

TP53

− 2.129

Activated

3.271

7.29E−48

726

MYC

− 2.262

Activated

5.269

6.14E−33

486

CTNNB1

5.332

Activated

4.818

3.26E−28

384

SMARCA4

2.68

Activated

2.141

1.39E−18

256

STAT3

− 3.854

Activated

2.077

6.50E−14

236

HNF1A

− 2.214

Inhibited

− 4.778

5.03E−20

213

HIF1A

6.735

Activated

4.443

1.26E−13

176

PPARGC1A

47.619

Inhibited

− 5.494

1.69E−19

168

POU5F1

− 4.011

Activated

3.538

1.80E−06

123

YAP1

4.979

Activated

3.935

1.89E−11

117

SMAD3

2.214

Activated

3.208

5.88E−11

116

KLF3

− 2.047

Inhibited

− 2.844

4.20E−05

115

NOTCH1

2.518

Activated

2.574

9.65E−06

98

MITF

2.081

Activated

3.233

3.52E−05

87

ETS1

19.431

Activated

2.415

1.34E−05

84

TWIST1

6.797

Activated

2.226

1.63E−10

79

SOX4

50.964

Activated

3.166

2.79E−06

75

SMAD7

4.099

Inhibited

− 2.615

1.64E−10

74

MYB

− 2.015

Activated

3.237

2.10E−05

69

EGR1

− 6.18

Activated

2.985

1.19E−03

66

LEF1

11.741

Activated

2.657

1.37E−05

61

CBX5

3.806

Inhibited

− 3.141

3.15E−09

59

RBPJ

2.248

Inhibited

− 2.082

1.14E−04

59

NFAT5

2.319

Activated

2.291

2.97E−07

48

MLXIPL

− 6.246

Activated

4.068

4.44E−04

47

TEAD1

2.73

Activated

3.536

3.29E−08

39

IRF7

− 4.895

Inhibited

− 3.731

1.00E+00

39

MTPN

2.647

Activated

3.39

1.23E−04

36

KLF5

15.642

Activated

3.404

4.43E−06

31

HAND2

14.283

Activated

2.342

2.90E−04

30

PLAG1

18.451

Activated

2.835

2.52E−04

26

KLF15

12.019

Inhibited

− 3.222

4.42E−04

23

E2F6

2.874

Inhibited

− 2.32

3.98E−02

22

NFATC4

6.717

Activated

2.088

7.85E−03

15

EED

4.823

Inhibited

− 2.121

1.59E−01

14

ETV1

− 3.182

Activated

2.085

4.82E−04

14

CREB3L3

− 9.434

Inhibited

− 2.977

4.82E−04

14

SMARCD3

3.952

Activated

2.891

1.69E−04

13

MTDH

− 2.891

Activated

2.026

1.06E−01

13

BTG2

7.736

Inhibited

− 2.109

2.82E−02

11

NFIX

− 5.255

Inhibited

− 2.159

9.42E−03

11

CREBZF

2.133

Activated

3.105

8.44E−03

10

STAT2

− 2.78

Inhibited

− 2.38

1.00E+00

10

GLIS2

10.34

Inhibited

− 2.333

1.85E−02

9

PKNOX1

3.15

Activated

2.408

3.92E−02

9

NLRC5

− 6.873

Inhibited

− 2.053

2.50E−01

7

HIF3A

10.89

Inhibited

− 2.415

7.79E−02

6

JARID2

5.327

Inhibited

− 2.176

7.79E−02

6

SERTAD2

3.181

Activated

2.387

1.45E−01

6

ZFPM2

5.634

Activated

2.236

3.64E−01

5

TRIM25

− 2.353

Inhibited

− 2.195

1.12E−01

5