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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application

Fig. 2

Comprehensive management of the production of hMSCs for transplantation. Isolated MSCs should be selected based on the analysis of the gene-wide profile. Selected MSCs are cultured with preconditioning factors, especially key molecules in the pathogenesis of the target disease, and during the period, the property of the selected cells has to be maintained. Also, the therapeutic function of MSCs can be enhanced by genetic modification. The therapeutic function is repeatedly validated with proper disease models. To improve the therapeutic outcomes, optimizing the condition of administration such as the adequate time point is important, and MSCs are able to be applied with biocompatible substances or advanced medical technologies

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