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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Peripheral blood-derived monocytes show neuronal properties and integration in immune-deficient rd1 mouse model upon phenotypic differentiation and induction with retinal growth factors

Fig. 5

Analysis of transplanted animals for cGMP levels and inflammatory markers. a The serum level of cGMP was significantly reduced in post transplanted animals eye lysate samples also exhibited a slight reduction in total cGMP content post transplantation. (wild type) BALB/c, (rd1 model) CBA/J, transplanted animals (NOD-SCID-rd1). b qPCR analysis in transplanted animals suggested that pro-inflammatory cytokines such as TNF-a while anti-inflammatory cytokines such as IL-7 and IL-10 were exacerbated. The expression of MAC-1- and CD14-positive cells were upregulated while NK, (T cells) CCL2 and (Neutrophils) Ly6G had no noticeable difference. PEDF, a neuroprotective growth factor, was upregulated while VEGF showed no change (n = 4)

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Stem Cell Research & Therapy

ISSN: 1757-6512