Table 2 Some of the keratinocyte-derived extracellular vesicle components and their biological functions
From: Shedding light on the role of keratinocyte-derived extracellular vesicles on skin-homing cells
CD9 | Exosome biogenesis pathways, cell adhesion |
CD63 | Exosome biogenesis pathways |
hsa-miR 22 | Regulation of cell proliferation and apoptosis |
hsa-miR 27b | Fibroblast activation |
hsa-miR 21 | Keratinocyte migration, fibroblast migration and differentiation, fibroblast-mediated angiogenesis and pro-inflammatory response |
miRNA-203, miRNA-205 | Regulation of keratinocyte proliferation and migration |
Cathepsin B | Intracellular proteolysis |
Hsp70 | Cytoprotection |
Annexin II | Biogenesis of the EVs |
Mac-2BP | Cell adhesion and host defense |
TGF-β | Stimulation of fibroblast to express collagen |
EGF, involucrin, KLK7, MAPK3 | Keratinocyte differentiation |
Jagged-1 | Regulation of fibroblasts growth factor |
PAI-1 | Keratinocytes adhesion and migration |
MMPs | Extracellular matrix degradation |
LDH | Stimulation of VEGF production |
14-3-3σ | Stimulation of fibroblast to express collagen |
14-3-3 γ/β | PKC inhibition |
14-3-3ε | Signal transduction and cell division |
14-3-3ζ | Regulation of insulin sensitivity |
14-3-3Ï„ | Regulation of protein kinase |
ITG | Communication between keratinocytes and fibroblasts |
Hsp90α | Pro-motility factor for the migration of keratinocytes, fibroblasts and endothelial cells |