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Fig. 9 | Stem Cell Research & Therapy

Fig. 9

From: Inhibition of hypertrophy and improving chondrocyte differentiation by MMP-13 inhibitor small molecule encapsulated in alginate-chondroitin sulfate-platelet lysate hydrogel

Fig. 9

The effect of mechanical loading on chondrogenesis of hBM-MSCs in Alg-CS-PL hydrogels in the absence or presence of 39 μM BICA at day 28. a qRT-PCR of loaded samples normalized to unloaded samples. b GAG deposition of loaded and unloaded samples (−) without and (+) with BICA. c Collagen content of loaded and unloaded samples. d Toluidine blue and Safranin-O and fast green staining of loaded samples with and without BICA. Data are presented as means ± SD (n = 2) (*p < 0.05, **p < 0.01, ***p < 0.001)

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