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Fig. 2 | Stem Cell Research & Therapy

Fig. 2

From: Both Wnt signaling and epidermal stem cell-derived extracellular vesicles are involved in epidermal cell growth

Fig. 2

Wnt/β-catenin signaling promotes stemness and function of interfollicular epidermal stem cells (EpSCs). Immunostaining of β-catenin (a), K14 and K10 (b), and Ki67 (d) in EpSCs treated with Wnt3a or XAV939. c mRNA expression of PCNA in EpSCs treated with Wnt3a or XAV939. e Proliferation curve of EpSCs analysis in EpSCs treated with Wnt3a or XAV939. mRNA expression of MMPs (f), BM components (g), keratinocyte differentiation associated genes (h), and EMT associated genes (I), in EpSCs treated with Wnt3a or XAV939. All biological experiments were repeated three times (n = 3, biological replicates; data displayed as mean ± SEM, *p < 0.05, **p < 0.01)

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Stem Cell Research & Therapy

ISSN: 1757-6512