Fig. 3

scRNA-Seq identification of lung B cell compartment in the vehicle control and LPS groups. a Violin plots showing the log-transformed expression of selected genes, Ccl3, Ccl4, and Cd86, in the PBS group, and in mice at 3 and 7 days after LPS treatment. *P < 0.05, **P < 0.01, ***P < 0.001, Wilcoxon test. b Top 20 functional enrichment analysis with KEGG analysis using DEGs between the PBS group and mice at 3 days after LPS treatment. The x-axis represents the gene ratio. c Bar plot of the DEGs between the PBS group and mice at 3 days after LPS treatment involved in biological process terms of GO functional enrichment analysis. d Gene set enrichment analysis (GSEA) of the response to IFN-γ (GO: 0071346) in the DEGs between the vehicle control group and 3 days after LPS treatment. Black bars indicate positions of the response to IFN-γ in the ordered list of genes. The green line indicates line of running enrichment score. The red broken line represents the gene with the highest enrichment score. P < 0.01