Fig. 6

PTK2 targeted miR-138-5p directly, and upregulation of PTK2 repressed autophagy in SAP. a Potential bind sites of rno-miR-138-5p in PTK2 3′-UTR. b PTK2-wt or PTK2-mut plasmid was co-transfected with miR-NC or miR-138-5p mimics into 293T cells for 24 h, then luciferase activity was detected. c Relative mRNA expression of PTK2 in MSCs with different administrations analyzed by qRT-PCR. d–k Western blot analysis of pancreatic FAK, PDK1, AKT, p-AKT, mTOR, p-mTOR, P62, Beclin-1, and LC3 protein levels. Data represent means ± SD from at least three separate experiments. n = 6/group. *p < 0.05, **p < 0.01, ***p < 0.001. NS, not significant