Fig. 2

Cluster analysis of differentially expressed proteins in R28 cells. MaxQuant version 1.5.8.3 (www.coxdocs.org) for label-free quantification (LFQ) was used to identify differentially expressed proteins in treated groups (exosome, CoCl₂, and CoCl₂ + exosome) and PBS-treated control cells. a Heatmap of differentially expressed proteins (p ≤ 0.05 and log2FC ≥ 1) in lysates of four groups (control, exosome, CoCl₂, and CoCl₂ + exosome) analyzed by hierarchical clustering. High expression is shown in red; low expression is shown in green. b Venn diagram showing the number of proteins identified in proteomic analysis of experimental groups of R28 cells. c Graph presenting the number of significantly up- and downregulated proteins in experimental groups (p < 0.05)