Fig. 1

Dose finding and optimization for small molecules (SB, Bpv, NAM, Pur, PD, Chir, Pμ). In each graph, the middle column corresponds to the reference concentration of the small molecules based on the literatures. Cell viability was measured by MTS assay post 48 h incubation with small molecules. The negative control in each group was used for the normalization of data. Bars indicated as mean ± SD at least five independent replicates. *P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.001, ****P ≤ 0.0001