Table 1 Studies in favor of that ADSCs may increase the risk of breast cancer
Reference | Year | ADSCs origin | ADSCs surface marker | Results |
|---|---|---|---|---|
Razmkhah et al. [103] | 2010 | Human breast (normal versus cancer-affected) | CD44+ CD105+ CD166 + CD14− CD34− CD45− | Cancer-affected ADSCs expressed higher levels of VEGF, IL-8, HGF, and IGF-1 |
Yan et al. [104] | 2012 | Human breast (normal versus cancer-affected) | CD29+CD73+CD90+CD105+ CD166+ CD31−CD144−CD14−CD45− HLA-DR− | ADSCs promoted the proliferation of MCF-7 via EGF/EGFR/Akt (cancer-affected > normal) |
Devarajan et al. [92] | 2012 | Human whole fat | – | ADSCs promoted the proliferation and EMT markers expression of multiple breast cancer cell lines |
Orecchioni et al. [105] | 2013 | Human lipoaspirates | CD13+CD34+CD140b+ CD31−CD45− | ADSCs promoted the proliferation of multiple breast cancer cell lines (MDA-MB-436, HCC1937, and ZR75–1) and EMT markers expression in ZR75–1 |
Lin et al. [106] | 2013 | Human lipoaspirates | – | ADSC-derived exosomes promoted the proliferation of MCF-7 cells via activating Wnt signaling |
Eterno et al. [107] | 2014 | Human lipoaspirates and breast whole fat (normal versus cancer-affected) | CD44+CD90+CD117+ CD133+ CD34lowCD45− | ADSCs are not tumorigenic; ADSCs stimulated the proliferation, migration and tumorigenic behavior of MDA-MB-231 but not MCF-7 via HGF/c-Met |
Trivanović et al. [108] | 2014 | Human breast (normal vs. cancer-affected); abdominal | CD44+CD73+CD90+CD105+ CD11a−CD33−CD45−CD235a− | ADSCs from all sources exhibited similar character and enhanced the proliferation of MCF-7 via direct co-culture |
Sakurai et al. [109] | 2017 | Human subcutaneous fat | – | ADSC-derived CM promoted the proliferation of multiple breast cell lines |
Melzer et al. [110] | 2018 | Umbilical cord explant cultures | – | The hybrid of ADSCs with MDA-MB-231 cells developed elevated metastatic capacities. |
Xu et al. [111] | 2019 | Mice inguinal fat tissues | – | ADSCs stimulated the migration and invasion of 4T1 cells via c-Kit/MAPK-p38/E2F1 signaling |
Lyes et al. [112] | 2019 | Zenbio (ASC-F) | – | ADSCs CM increased proliferation of the chemo-residual TNBC cells relying on FGF2 |
Fajka-Boja et al. [113] | 2020 | Mice visceral fat tissues | – | ADSCs promoted 4T1 cells growth and metastasis via IGF/IGFBP |