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Table 1 Studies in favor of that ADSCs may increase the risk of breast cancer

From: Adipose tissue-derived stem cells in breast reconstruction: a brief review on biology and translation

Reference Year ADSCs origin ADSCs surface marker Results
Razmkhah et al. [103] 2010 Human breast (normal versus cancer-affected) CD44+ CD105+ CD166 +
CD14 CD34 CD45
Cancer-affected ADSCs expressed higher levels of VEGF, IL-8, HGF, and IGF-1
Yan et al. [104] 2012 Human breast (normal versus cancer-affected) CD29+CD73+CD90+CD105+
CD166+
CD31CD144CD14CD45
HLA-DR
ADSCs promoted the proliferation of MCF-7 via EGF/EGFR/Akt (cancer-affected > normal)
Devarajan et al. [92] 2012 Human whole fat ADSCs promoted the proliferation and EMT markers expression of multiple breast cancer cell lines
Orecchioni et al. [105] 2013 Human lipoaspirates CD13+CD34+CD140b+
CD31CD45
ADSCs promoted the proliferation of multiple breast cancer cell lines (MDA-MB-436, HCC1937, and ZR75–1) and EMT markers expression in ZR75–1
Lin et al. [106] 2013 Human lipoaspirates ADSC-derived exosomes promoted the proliferation of MCF-7 cells via activating Wnt signaling
Eterno et al. [107] 2014 Human lipoaspirates and breast whole fat (normal versus cancer-affected) CD44+CD90+CD117+
CD133+
CD34lowCD45
ADSCs are not tumorigenic; ADSCs stimulated the proliferation, migration and tumorigenic behavior of MDA-MB-231 but not MCF-7 via HGF/c-Met
Trivanović et al. [108] 2014 Human breast (normal vs. cancer-affected); abdominal CD44+CD73+CD90+CD105+
CD11aCD33CD45CD235a
ADSCs from all sources exhibited similar character and enhanced the proliferation of MCF-7 via direct co-culture
Sakurai et al. [109] 2017 Human subcutaneous fat ADSC-derived CM promoted the proliferation of multiple breast cell lines
Melzer et al. [110] 2018 Umbilical cord explant cultures The hybrid of ADSCs with MDA-MB-231 cells developed elevated metastatic capacities.
Xu et al. [111] 2019 Mice inguinal fat tissues ADSCs stimulated the migration and invasion of 4T1 cells via c-Kit/MAPK-p38/E2F1 signaling
Lyes et al. [112] 2019 Zenbio (ASC-F) ADSCs CM increased proliferation of the chemo-residual TNBC cells relying on FGF2
Fajka-Boja et al. [113] 2020 Mice visceral fat tissues ADSCs promoted 4T1 cells growth and metastasis via IGF/IGFBP