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Table 2 Studies contradicted to the promotion effect of ADSCs on breast cancer

From: Adipose tissue-derived stem cells in breast reconstruction: a brief review on biology and translation

Reference Year ADSCs origin ADSCs surface marker Results
Sun et al. [117] 2009 Human breast fat ADSCs reduced lung metastasis and inhibited the growth of human breast cancer cells by inducing apoptosis in mice model
Zimmerlin et al. [115] 2011 Human Subcutaneous adipose tissue ADSCs enhance the growth of active metastatic pleural effusion cells, but not resting tumor cells
Kucerova et al. [116] 2013 Human lipoaspirates CD44+CD73+CD90+CD105+
CD14CD34CD45
ADSCs inhibited the proliferation of SKBR3 cells via SDF-1α/CXCR4 and increased chemosensitivity in a paracrine manner
Trivanović et al. [108] 2014 Human breast (normal versus cancer-affected) and abdominal CD44+CD73+CD90+CD105+
CD11aCD33CD45CD235a
ADSC-derived CM showed antiproliferative activity
Wu et al. [119] 2019 Human lipoaspirates ADSC-derived CM reduced cell viability by triggering apoptosis in MCF-7, MDA-MB231, and MDA-MB468 cells via ATM-Chk2-dependent DNA damage response
Plava et al. [118] 2020 Breast adipose tissue of healthy donors, adipose tissue adjacent to pre-malignant lesions or malignant lesions or malignant lesions with BRCA mutation CD90+ CD105+ CD73+
CD14- CD20 CD34 CD45
Cancer-related ADSCs displayed a significant enhancement on the proliferation and metastasis of JIMT but exhibited a weak promotion effect on T47D and no effect on MDA231