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Fig. 1 | Stem Cell Research & Therapy

Fig. 1

From: The potential therapy with dental tissue-derived mesenchymal stem cells in Parkinson’s disease

Fig. 1

Main ways to exert the curative effects of DPSCs and SHED in PD models. Both genetic factors and environmental toxins can cause damage to DAergic neurons and then induce PD. DPSCs and SHED can be isolated from the tissue of teeth. On the one hand, DPSCs and SHED can be directly transplanted into PD animal models for treatment through different delivery methods. On the other hand, DPSCs and SHED can be induced to differentiate into DAergic neuron-like cells in vitro and then be transplanted in several ways. In addition, DPSCs and SHED can secrete signal transduction proteins, nerve growth factors, and extracellular vesicles to repair damaged neurons. Extracellular vesicles are mainly composed of microvesicles and exosomes. Exosomes of appropriate size can also be transferred to the animal model by several delivery methods. There are many means to transplant, such as intravenous injection, intranasal injection, and intracerebral injection

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