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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: TUG1 enhances high glucose-impaired endothelial progenitor cell function via miR-29c-3p/PDGF-BB/Wnt signaling

Fig. 8

TUG1 overexpression promotes angiogenesis in diabetic mice. a Representative evaluation of the ischemic (right) and non-ischemic (left) hind limbs before and 4 weeks after surgery. In color-coded images, red indicates normal perfusion and blue indicates a marked reduction in blood flow in the ischemic hind limb. b Blood perfusion was measured using a Laser Doppler perfusion imager system from prior to the operation to 4 weeks after the operation. *p < 0.05 vs diabetes. c CD31 immunostaining of gastrocnemius muscle tissue after 4 weeks of hind limb ischemia. Scale bar = 100 μm. d Capillary density as expressed by isolectin-positive capillaries per muscle fiber. *p < 0.05 vs diabetes

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