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Table 1 Studies demonstrating the MSC-EV-mediated transfer of miRNAs in animal models

From: Potential application of mesenchymal stem cells and their exosomes in lung injury: an emerging therapeutic option for COVID-19 patients

miRNA transferred Target proteins Function Reference
miR-let7c TGF-β receptor 1 Anti-fibrotic [104]
miR-30 Dynamin-related protein 1
(DRP1)
Regulate mitochondrial fission [105]
miR-22 Methyl-CpG-binding protein 2 (Mecp2) Anti-fibrotic [106]
miR-19a PTEN Cell survival signaling pathway [107]
miR-223 Semaphorin 3A (Sema3A) and Stat3 Anti-apoptotic and antiinflammatory [108]
miR-122 Cyclin G1, IGF1R, and P4HA1 Anti-proliferative and antifibrotic [109]
miR-223 NLRP3 Anti-inflammatory: decrease pytoptosis and IL-1β [110]
miR-181 Bcl-2 and Stat3 Anti-fibrotic and activated autophagy [111]
miR-133 RhoA and connective tissue growth factor Enhanced plasticity [112]
miR-17-92 PTEN Cell survival signaling pathway [113]
  1. IGF1R insulin-like growth factor receptor 1, P4HA1 prolyl 4-hydroxylase alpha 1, NLRP3 NLR pyrin domain-containing 3, RhoA homolog gene family member A, BCL-2 B cell lymphoma 2 family