Table 1 Various miRNAs regulating osteoblast differentiation of MSCs
miRNA | Target | Feature | Reference(s) |
|---|---|---|---|
miR-2861 | HDAC5 | - Induces osteoblast differentiation | [68] |
miR-433-3p | DKK1/Wnt/β-catenin pathway | - Induces osteoblast differentiation through decreasing DKK1 expression | [69] |
miR-199b-5p | GSK-3b | - Promotes osteoblast differentiation | [70] |
miR-15b | Smurf1 | - Promotes osteoblast differentiation by indirectly protecting Runx2 protein from Smurf1-mediated degradation | [71] |
miR-503 | Smurf1 | - Induces osteogenic differentiation via suppressing Smurf1 expression | [72] |
miR-22 | HDAC6 | - Promotes osteogenesis and inhibits adipogenesis by repressing HDAC6 | [66] |
miR-20a | PPARγ, Bambi, and Crim1 | - Promotes osteogenesis of hMSCs by upregulation of BMP/Runx2 signaling | [73] |
miR-31, miR-93, and miR-145 | Osx | - Suppresses osteogenic differentiation | |
miR-139-5p | Frizzled (FZD) | - Suppresses osteogenic differentiation | [77] |
miR-154-5p | Wnt/PCP signals | - Negative regulation of ADSC osteogenic differentiation | [78] |
miR-26a-5p | Wnt5a | - Suppresses osteogenic differentiation | [79] |
miR-204/211 | Runx2 | - Inhibits osteogenesis and promotes adipogenesis of BMSCs | [80] |