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Fig. 8 | Stem Cell Research & Therapy

Fig. 8

From: Circular RNA SIPA1L1 regulates osteoblastic differentiation of stem cells from apical papilla via miR-204-5p/ALPL pathway

Fig. 8

CircSIPA1L1/miR-204-5p/ALPL regulates osteogenic differentiation of SCAPs. a Results of western blot analysis indicated that the miR-204-5p inhibitor rescued the si-SIPA1L1 mediated downregulation of ALP, RUNX2, and OSX. GAPDH served as an internal control. Histograms showed the quantification of band intensities. b Results of qRT-PCR analysis revealed the miR-204-5p inhibitor rescued the si-SIPA1L1 mediated downregulation of ALPL, RUNX2, and OSX. c, d ALP staining and ALP activity assay showed the miR-204-5p inhibitor rescued the si-SIPA1L1 mediated downregulation expression of ALP. e Schematic diagram for circSIPA1L1/ miR-204-5p /ALPL axis. *P < 0.05, **P < 0.01, and ***P < 0.001

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Stem Cell Research & Therapy

ISSN: 1757-6512