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Fig. 5 | Stem Cell Research & Therapy

Fig. 5

From: Epidermal stem cell-derived exosomes promote skin regeneration by downregulating transforming growth factor-β1 in wound healing

Fig. 5

EPSC-Exos inhibited the expression of transforming growth factor-β1 (TGF-β1) and its downstream genes to suppress myofibroblast formation. ad mRNA levels of TGF-β1, Smad2, α-SMA and collagen I in the healing tissue. e ESCs were co-cultured with HDF in Transwell plates (membrane well, 0.4 μm). IF and qRT-PCR were performed after culture for 48 h. f, g Expression levels of TGF-β1 of HDF in a co-cultured system using qRT-PCR and IF. Scale bar = 200 μm. ***P < 0.001; mean ± SD; n = 5. Ctrl, control; EGF, epidermal growth factor; EPSC-Exos, epidermal stem cell-derived exosomes; ESC, epidermal stem cell; HDF, human dermal fibroblast; TGF-β1, transforming growth factor β-1; α-SMA, α-smooth muscle actin; IF, immunofluorescence staining

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