Fig. 1

Establishment of the mouse POI model. a Schematic procedure of establishing the chemotherapy-induced POI model. b The comparison of body weight between the control and POI groups (n = 10). c The comparison of ovarian weight between the control and POI groups (n = 17). d, e The comparison of serum levels of FSH and E2 between the control and POI groups (n = 4). f H&E staining of ovarian sections from the control and POI groups. g The number of follicles at different developmental stages from the control and POI groups. Scale bar = 400 μm. All data were presented as the mean ± SD. One-way ANOVA with LSD and Tamhane’s T2 post hoc test were used for analysis. *P < 0.05; **P < 0.01; ***P < 0.001