Fig. 4

The offspring of POI mice increased in number after hUCMSC transplantation and manifested normal behavior. a Schematic procedure of hUCMSC treatment. b Fertility test of three groups of mice. The test was performed at 1, 2, and 3 months after hUCMSC transplantation. The number of offspring per liter was analyzed (n = 15, n = 15, n = 15). Behavioral tests of the offspring in the three groups (n = 4, n = 5, n = 5) include c grip strength, d velocity, e total distance, f length of duration, and g times of entry into the center. All data were presented as the mean ± SD. One-way ANOVA with LSD and Tamhane’s T2 post hoc test were used for analysis. *P < 0.05; **P < 0.01; ***P < 0.001