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Fig. 10 | Stem Cell Research & Therapy

Fig. 10

From: Development and validation of a novel stem cell subtype for bladder cancer based on stem genomic profiling

Fig. 10

Identification of key genes/networks based on WGCNA for BLCA stem cell subtypes. a Correlation heat map of 14 modules in 3 stem cell subtypes obtained from 4876 differential genes compared to normal tissues and BLCA of TCGA cohort. b In the brown module, the co-expression network is composed of IRF5 and GATA3. c In the black module, the co-expression network is composed of GRHL2 and GATA6. d Top 20 enrichment pathways obtained by using Metascape in the black module. f Top 20 enrichment channels arranged by -Log10P value in the black module. g Differential expression of GATA3 and h GATA6 in BLCA stem cell subtypes, Wilcoxon tests, *P < 0.05, **P < 0.01, ***P < 0.001. i GATA3 and j GATA6 Kaplan–Meier survival curve according to the median expression level using GEPIA, log-rank test. BLCA, bladder cancer; TCGA, The Cancer Genome Atlas; WGCNA, weighted correlation network analysis

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