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Fig. 7 | Stem Cell Research & Therapy

Fig. 7

From: Development and validation of a novel stem cell subtype for bladder cancer based on stem genomic profiling

Fig. 7

Stem cell stratification analysis of BLCA based on CD274 and stem gene expression. The scatter plot shows the gene expression value of CD274 and stemness genes (CD44, GATA3, HIF1A, ID1, MYC, SOX9, CXCL8) after log2 conversion (ag). Log-rank test was used to determine the best cutoff value to divide continuous variables of gene expression into high and low expression groups. The blue arrow shows the highest test score of the candidate cutoff point based on the gene expression value of the log2 transformation, so the patients were divided into 4 different risk groups (blue dotted line, groups I–IV). The risk groups are those with their proportions expressed as percentages. A linear regression line was drawn; the gray-shaded area shows the 95% confidence interval, and the correlation analysis revealed the Pearson correlation coefficient. The SCE_H (black triangle), SCE_M (gray circle), and SCE_L (brown diamond) status are marked as BLCA samples. h Correlation diagram of CD274 and stem genes, Pearson correlation coefficient; red indicates positive correlation, and green indicates negative correlation. io Kaplan–Meier survival curves of risk groups I and III were plotted, log-rank test. SCE_H, high stem cell enrichment; SCE_M, medium stem cell enrichment; SCE_L, low stem cell enrichment; BLCA, bladder cancer

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